Key result
Perioperative and postoperative prophylaxis with dalteparin significantly reduced thromboembolism compared to no prophylaxis in ambulatory arthroscopic knee surgery (1.5% vs 15.6%; P=0.004).
Why the study?
Does dalteparin reduce the incidence of deep vein thrombosis in outpatients undergoing ambulatory arthroscopic knee surgery?
Population
130 outpatients scheduled for ambulatory arthroscopic knee surgery
Comparison
Dalteparin 2,500 IU or 5,000 IU started… vs No prophylaxis
Design
RCT, Randomized, Single-blind
Follow-up
31 days
Authors
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Supports dalteparin prophylaxis in ambulatory knee arthroscopy; extends LMWH evidence to outpatient settings.
RCT (n=130)
Single-blind
randomized
Does dalteparin reduce the incidence of deep vein thrombosis in outpatients undergoing ambulatory arthroscopic knee surgery?
Absolute Event Rate: 1.5% vs 15.6%
p-value: p=0.004
Perioperative and postoperative prophylaxis with dalteparin significantly reduces the risk of deep vein thrombosis in patients undergoing ambulatory arthroscopic knee surgery.
Michot et al. (2002) conducted an RCT in ambulatory arthroscopic knee surgery (n=130). dalteparin vs. no prophylaxis was evaluated on thromboembolism (95% CI 7.8-26.8, p=0.004). Perioperative and postoperative prophylaxis with dalteparin significantly reduced thromboembolism compared to no prophylaxis in ambulatory arthroscopic knee surgery (1.5% vs 15.6%; P=0.004).
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