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June 14, 2026Journal of Biochemicals and Phytomedicine

Phytochemical Synergy and Antibacterial Activity of Crude and Fractionated Extracts of Senna occidentalis and Croton zambesicus Targeting Multidrug-Resistant Pathogens

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Authors

OOOlumide OluyeleSBSamuel Oluwapelumi BankoleOAOluwaseun Ruth Adegoke

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Overview

Randomized trial evaluates antimicrobial activity of plant extracts against multidrug-resistant bacteria, suggesting new therapeutic options.

Key Points

  • This study aims to assess the antibacterial properties of Senna occidentalis and Croton zambesicus extracts against multidrug-resistant bacteria.
  • Extracts obtained through maceration and fractionation using liquid-liquid partitioning.
  • Antibacterial testing conducted via agar well diffusion and broth dilution methods.
  • Phytochemical analysis performed using gas chromatography-mass spectrometry (GC-MS).
  • Crude extracts showed inhibition zones between 12.67 ± 0.67 mm and 18.00 ± 0.00 mm.
  • MIC and MBC values demonstrated a shift from bacteriostatic to bactericidal effects.
  • Key phytochemical components included unsaturated fatty acids, long-chain aldehydes, and sesquiterpenes.

Cite This Study

Oluyele et al. (2026) studied this question.

synapsesocial.com/papers/6a2e47cdb1cc60ccdea8c3echttps://doi.org/10.34172/jbp.2026.6
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