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This study investigates the antidiabetic and organ-protective properties of cucumber peel powder and ethanol extract.

Phytochemical Fingerprints by GC–MS, Antidiabetic and Multiorgan Protective Effects of Cucumis sativus Peel: An Integrated In Vitro, In Vivo, and In Silico Study

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Randomized trial demonstrates antidiabetic and organ-protective effects in diabetic rats, indicating potential health benefits of cucumber peel.

This study investigates the antidiabetic and organ-protective properties of cucumber peel powder and ethanol extract.
36 male albino rats were divided into six groups, including a diabetic control and various treatment doses.
Cucumber peel treatments were administered via oral gavage for 28 days after inducing diabetes with alloxan.
GC-MS was used for chemical profiling and in silico studies evaluated the binding of phytoconstituents to α-amylase.
Treatment significantly reduced fasting blood glucose and improved insulin and lipid levels.
Histopathological analysis revealed restoration of pancreatic, liver, and kidney architecture.
Molecular docking showed 9,12,15-octadecatrienoic acid had a significant binding affinity of -6.00 kcal/mol toward α-amylase.

Tasleem et al. (2026) studied this question.

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Randomized trial demonstrates antidiabetic and organ-protective effects in diabetic rats, indicating potential health benefits of cucumber peel.