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June 15, 2026Addictive BehaviorsOpen Access

Moderators of the impact of e-cigarette provision on smoking cessation: secondary analyses from a large naturalistic randomized clinical trial in the US

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Authors

KKKatelyn R. KovalTSTracy SmithAWAmy E. Wahlquist

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Overview

Randomized trial explores effects of e-cigarettes on smoking cessation in adults who smoke, indicating no differing outcomes by demographic or smoking history factors.

Key Points

  • This study aims to evaluate how individual characteristics affect the effectiveness of e-cigarettes for smoking cessation.
  • Randomized clinical trial with 638 adults who smoke, comparing e-cigarette provision and a control group.
  • Participants received a 4-week supply of e-cigarettes with minimal guidance on usage.
  • Outcomes assessed included quit attempts, reduction in smoking, and abstinence over 24 weeks.
  • No significant interactions found between demographic or smoking history variables and cessation outcomes.
  • Higher motivation to quit was associated with raw cessation outcomes, but RR for ≥ 50% reduction in smoking was consistent across motivation levels.
  • Overall, e-cigarettes’ effects on smoking cessation did not vary among different subgroups.

Cite This Study

Koval et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97c8a1cfeec490828cefhttps://doi.org/10.1016/j.addbeh.2026.108772
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1E-Cigarette Characteristics and Cigarette Cessation Among Adults Who Use E-Cigarettes2024 · 24 citations
  2. 2Individual-level predictors of cessation behaviours among participants in the International Tobacco Control (ITC) Four Country Survey2006 · 510 citations
  3. 3A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation2018 · 202 citations
  4. 4Motivational factors predict quit attempts but not maintenance of smoking cessation: Findings from the International Tobacco Control Four country project2010 · 215 citations
  5. 5Effect of unguided e-cigarette provision on uptake, use, and smoking cessation among adults who smoke in the USA: a naturalistic, randomised, controlled clinical trial2023 · 84 citations