Key result
Five monoclonal antibodies against Seneca Valley Virus VP2 protein identified the 153QELNEE158 peptide as the smallest linear neutralizing epitope, with E157 being the pivotal point for neutralization.
Why the study?
Seneca Valley virus causes vesicular disease in swine clinically similar to foot-and-mouth disease, making the development of tools to detect infection critical and urgent.
The identification of a conserved neutralizing epitope in the SVV VP2 protein provides insights for developing diagnostic tools and novel vaccines against Seneca Valley virus.
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SVV epitope-specific neutralizing antibodies generated; leaves open diagnostic validation and field utility in swine.
Wen et al. (2021) studied Seneca Valley Virus (SVV) infection. Monoclonal antibodies against SVV VP2 protein was evaluated on Identification of neutralizing epitope. Five monoclonal antibodies against Seneca Valley Virus VP2 protein identified the 153QELNEE158 peptide as the smallest linear neutralizing epitope, with E157 being the pivotal point for neutralization.
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