Why the study?
Therapeutic shunting unloads the left atrium in heart failure, but there is concern interatrial shunts could adversely impact the right heart or accelerate RV dilation and dysfunction.
Does left atrial-to-coronary sinus shunting adversely impact right ventricular function in patients with heart failure?
Does left atrial-to-coronary sinus shunting adversely impact right ventricular function in patients with heart failure?
This early feasibility study follow-up investigates the long-term impact of left atrial-to-coronary sinus shunting on right ventricular function in heart failure patients.
Exertional dyspnea attributable to elevations in left atrial pressure (LAP) is a hallmark symptom of heart failure. As an adjunct to guideline-directed medical therapy, therapeutic shunting devices have been explored as a mechanism to unload the left atrium, decongest the lungs, and relieve symptoms. However, studies in longitudinal heart failure have demonstrated a propensity for progressive right ventricular (RV) dilation and dysfunction, particularly among patients with heart failure with preserved ejection fraction (HFpEF), and thus, there is a legitimate concern that interatrial shunts could adversely impact the right heart or accelerate this process.
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Buchanan et al. (2026) studied Heart failure. Left atrial-to-coronary sinus shunting was evaluated.
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