Key result
Unidirectional left-to-right interatrial shunting may treat chronic systolic HF by reducing left atrial pressures.
Why the study?
Heart failure with reduced ejection fraction remains a significant clinical problem with poor quality of life, frequent hospital admissions, and high mortality despite advances in therapies.
Does unidirectional left-to-right interatrial shunting reduce left atrial pressures in patients with chronic systolic heart failure?
Does unidirectional left-to-right interatrial shunting reduce left atrial pressures in patients with chronic systolic heart failure?
Proposes the hypothesis that unidirectional left-to-right interatrial shunting could serve as a novel therapy for chronic systolic heart failure by reducing left atrial pressures.
Hypothesis-generating for interatrial shunting in systolic HF; prospective RCTs required before any clinical consideration.
Despite recent advances in pharmacologic and device-based therapies, heart failure with reduced ejection fraction remains an important clinical problem that is associated with poor quality of life, frequent hospital admissions and high mortality rates. The clinical deterioration and symptoms of these patients are directly related to volume overload and increased left atrial filling pressures with pulmonary congestion. This concept forms the basis for the hypothesis that unidirectional left-to-right interatrial shunting could provide a novel therapy for chronic systolic heart failure by reducing left atrial pressures.
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Torsten Vahl (2017) conducted a review in Heart failure with reduced ejection fraction in ischemic cardiomyopathy. Unidirectional left-to-right interatrial shunting was evaluated. Unidirectional left-to-right interatrial shunting is hypothesized to provide a novel therapy for chronic systolic heart failure by reducing left atrial pressures.
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