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The authors advocate for indication-guided and phenotype-guided de-escalation of beta-blockers rather than universal discontinuation in post-myocardial infarction patients without reduced LVEF.
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This letter contextualizes recent trial data, suggesting that beta-blocker de-escalation after uncomplicated MI with LVEF >40% should be indication- and phenotype-guided rather than abruptly discontinued.
Na Zhang, Yiqun Lou; Beta-blockers after myocardial infarction: indication, ejection fraction, and de-escalation pathway, European Heart Journal - Cardiova
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Zhang et al. (2026) conducted a letter in Myocardial infarction without reduced left ventricular ejection fraction. Beta-blockers vs. De-escalation or discontinuation was evaluated. The authors advocate for indication-guided and phenotype-guided de-escalation of beta-blockers rather than universal discontinuation in post-myocardial infarction patients without reduced LVEF.
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