Key result
Percutaneous VSD closure is linked to improved LV volumes, strain, and LVEF to ~65%.
Why the study?
Ventricular septal defect is the most common congenital heart disease, and evaluation of left ventricular systolic function before and after percutaneous trans-catheter device closure is needed.
Does percutaneous trans-catheter device closure improve left ventricular systolic function measured by speckle tracking echocardiography in patients with ventricular septal defect?
Cohort (n=20)
Yes
Does percutaneous trans-catheter device closure improve left ventricular systolic function measured by speckle tracking echocardiography in patients with ventricular septal defect?
Answers are grounded in this paper and cite their sources.
Transcatheter VSD closure effectively reduces left ventricular volume overload and improves contractility, as demonstrated by improvements in longitudinal strain and ejection fraction.
Background: Of all congenital heart Diseases, ventricular septal defect (VSD) accounts for 40%, making it the most common. More than 20% of congenital heart Diseases are caused by an isolated VSD. Aim: To evaluate Left Ventricular systolic function before and after VSD percutaneous trans-catheter device closure using 2D speckle tracking echocardiography. Subjects and methods: Twenty patients with VSD undergoing percutaneous trans-catheter device closure at Al-Azhar University hospitals in Cairo, Egypt, were the subjects of this prospective cohort study, conducted from August 2024 to August 2025. Results: After percutaneous trans-catheter device closure, the levels of LVEDD 42.2±3.8, LVESD 28.7±2.9, LVEDV 89.3±17.2, and LVESV 31.3±8 were significantly decreased , and EF by M-mode 68.5±2 and modified Simpson’s method 65.3±2.9 was significantly improved. Also, circumferential strain was significantly decreased (less negative) -26.5±0.3 and longitudinal strain was significantly improved (more negative) -19.8±0.5. Conclusion: Reduced LV volume overload and improved contractility are the results of transcatheter VSD closure, which causes an increase in longitudinal strain and a decrease in circumferential strain.
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Hefny et al. (2026) conducted a cohort in ventricular septal defect (VSD) (n=20). percutaneous trans-catheter device closure vs. baseline (before closure) was evaluated on Left Ventricular systolic function using 2D speckle tracking echocardiography. Percutaneous trans-catheter VSD closure reduced LV volumes and improved ejection fraction and longitudinal strain.
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