Histological Findings and Predictors of Cerebral Debris From Transcatheter Aortic Valve Replacement: The ALSTER Experience
Why the study?
What are the histological findings and predictors of cerebral debris captured by a cerebral protection system during transcatheter aortic valve replacement?
Population
161 patients undergoing transcatheter aortic valve replacement with a dual-cerebral-filter protection…
Design
Cohort
Authors
Discussion
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Member takes
Implication
High debris capture with female sex and diabetes as predictors; hypothesis-generating for cerebral protection in TAVR and should not yet change practice.
Structured PICO
What are the histological findings and predictors of cerebral debris captured by a cerebral protection system during transcatheter aortic valve replacement?
P
Population
161 patients undergoing transcatheter aortic valve replacement (TAVR) with a dual-cerebral-filter protection system, mean age 81 years, 51% male, median logistic EuroSCORE 19%.
I
Intervention
Dual-cerebral-filter protection system during transcatheter aortic valve replacement
O
Outcome
Embolic debris capture rate and histological compositionsurrogate
Embolic debris is captured in nearly all TAVR procedures using cerebral protection, consisting mainly of thrombus and arterial/valve tissue, with female sex and diabetes being significant predictors.
Cite This Study
Schmidt et al. (2016) studied this question.