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September 1, 2012EuroInterventionOpen Access

The effects of VARC-defined acute kidney injury after transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis

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Why the study?

What is the incidence and what are the risk factors for acute kidney injury after TAVI using the Edwards bioprosthesis?

Population

248 patients undergoing transcatheter aortic valve implantation (TAVI)

Design

Cohort

Follow-up

1 year

Authors

MKMuhammed Zeeshan KhawajaKing's College LondonMTMartyn ThomasSt Thomas' HospitalAJAbhishek JoshiBarts Health NHS Trust

Discussion

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Implication

AKI after TAVI signals higher 30-day and 1-year mortality; leaves open whether risk-factor modification improves survival.

Structured PICO

What is the incidence and what are the risk factors for acute kidney injury after TAVI using the Edwards bioprosthesis?

P
Population
248 patients undergoing transcatheter aortic valve implantation (TAVI)
I
Intervention
Transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis
O
Outcome
Incidence of acute kidney injury (AKI) defined as a VARC-modified RIFLE score ≥ 2, and mortality at 30 days and one yearsafety

More than one third of patients sustain acute kidney injury after TAVI using the Edwards bioprosthesis, which significantly increases mortality at 30 days and one year.

Cite This Study

Khawaja et al. (2012) studied this question.

synapsesocial.com/papers/6a323558cf42d9fde8ddca1fhttps://doi.org/10.4244/eijv8i5a87
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence and Prognostic Importance of Acute Renal Failure After Percutaneous Coronary Intervention2002 · 1,730 citations
  2. 2A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease2003 · 3,561 citations
  3. 3One-Year Outcomes of Cohort 1 in the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry2011 · 530 citations
  4. 4Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI)2008 · 175 citations
  5. 5Cost-Effectiveness of Transcatheter Aortic Valve Replacement Compared With Standard Care Among Inoperable Patients With Severe Aortic Stenosis2012 · 295 citations