Key result
Post-TAVI AKI is linked to a ~3-fold increase in mortality.
Why the study?
TAVI can result in serious complications including acute kidney injury, but the incidence, predictors, and prognosis of AKI after TAVI were not well characterized.
What is the incidence, predictors, and prognostic impact of acute kidney injury in patients undergoing TAVI?
Population
Patients with symptomatic aortic stenosis unfit for open heart surgery undergoing TAVI
Design
Single-center retrospective cohort study
Authors
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AKI after TAVI warrants close monitoring given its mortality association; leaves open whether prevention strategies improve outcomes in trials.
Cohort
No
What is the incidence, predictors, and prognostic impact of acute kidney injury in patients undergoing TAVI?
Hazard Ratio: 2.97 (95% CI 1.23–7.19)
p-value: p=0.016
Acute kidney injury is a frequent complication after TAVI (affecting >33% of patients) and is strongly associated with increased mortality, with baseline CKD and EuroSCORE-II serving as independent predictors.
Buttigieg et al. (2018) conducted a cohort in Symptomatic aortic stenosis unfit for open heart surgery. Acute kidney injury (AKI) vs. No acute kidney injury was evaluated on Mortality (HR 2.97, 95% CI 1.23-7.19, p=0.016). Acute kidney injury following TAVI occurred in over a third of patients and was established as a significant hazard for mortality (HR 2.97; 95% CI 1.23-7.19; p=0.016).
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