Mechanism study of governor vessel moxibustion on alleviating female rats’ hyperplasia of mammary gland via regulating the NF-κB signaling pathway

June 1, 2026Lishizhen medicine and materia medica research

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Key Points

This study aims to explore how moxibustion regulates the NF-κB signaling pathway to alleviate mammary gland hyperplasia in female rats.
40 female SD rats were randomly assigned to four groups: control, model, drug, and moxibustion, with 10 rats each.
The mammary gland hyperplasia model was induced using estrogen and progesterone; moxibustion was performed biweekly for 4 weeks.
Various assessments were conducted including tissue pathology, hormone levels via ELISA, mRNA expression via qRT-PCR, and protein levels via Western blot.
The model group showed increased mammary gland diameter and height, elevated serum E2, PRL, inflammatory cytokines, and decreased antioxidant levels (P<0.05).
Compared to the model group, both drug and moxibustion groups exhibited opposing effects on the aforementioned indicators (P<0.05).
Moxibustion potentially reduced hyperplasia by inhibiting the NF-κB signaling pathway and regulating hormone levels.

Examines moxibustion's effects on mammary gland hyperplasia in female rats, suggesting potential therapeutic benefits.

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Wang et al. (2026) studied this question.

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