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June 17, 2026Journal of Molecular PathologyOpen Access

Comparative Cytotoxicity and Inflammatory Profiles of CeraSeal Versus AH Plus in Periodontal Tissue Repair: An In Vitro and In Vivo Study

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Authors

GSGulnihol SharipovaBukhara State Medical InstituteJRJasur RizaevSamarkand State University named after Sharof RashidovSBShuxrat BoymuradovTashkent Pediatric Medical Institute

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Implication

In vitro and in vivo study compares cytotoxicity and inflammatory responses of CeraSeal and AH Plus, suggesting CeraSeal's biocompatibility.

Key Points

  • To compare the cytotoxicity and inflammatory profiles of CeraSeal and AH Plus in periodontal tissue repair.
  • Exposed human periodontal ligament stem cells to sealer extracts for 120 hours and assessed cell death through various assays.
  • Utilized a rat model to evaluate inflammatory markers and osteogenic activity with two sealer types.
  • Conducted morphometric analysis to assess cellular preservation and inflammatory infiltration.
  • AH Plus showed greater necrotic cell death (357.6% LDH release) compared to CeraSeal (128.8%; p = 0.0079).
  • In vivo analysis showed higher IL-1β levels in AH Plus-treated tissues (52.25 cells/mm²) than in CeraSeal (24.88; p = 0.0002).
  • CeraSeal demonstrated superior cellular preservation (p = 0.0079) despite higher inflammatory infiltration compared to AH Plus.

Cite This Study

Sharipova et al. (2026) studied this question.

synapsesocial.com/papers/6a323aead50b63ecad205abbhttps://doi.org/10.3390/jmp7020024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of cytotoxicity and adaptability of a novel bioceramic root canal sealer: An in vitro and scanning electron microscope study2024 · 6 citations
  2. 2Oxidative Stress, Pro-Inflammatory Response, Cytotoxicity and Apoptosis Induced by Contemporary Endodontic Sealers in Human Periodontal Ligament Fibroblasts2026 · 4 citations
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  4. 4Complications in Endodontics2020 · 36 citations
  5. 5Cytotoxicity and genotoxicity evaluation of AH Plus, Well-Root ST, and AH Plus Bioceramic Sealer2025 · 5 citations