紫外線照射不活化feline leukemia virusによるfeline α/β-interferon産生の抑制

The effects of ultraviolet-inactivated feline leukemia virus (UV-FeLV) on the production of α and/or βinterferon(IFN) by mononuclear cells stimulated with the Newcastle disease virus(IFN-NDV) was investigated. The production of IFN-NDV and γ IFN was suppressed by 50 % as compared to the control in the presence of 200 ng/ml or 200 μg/ml of UV-FeLV, respectively. The presence of UV-FeLV decreased the rate of the production, but the time to reach the plateau of the IFN activity in the culture supernatant was not shortened in both IFNs. It was suggested that the suppressive effects of UV-FeLV against both IFNs were through rather similar mechanisms. The suppressive effects of UV-FeLV on IFN-NDV production was most evident in the cultures to which UV-FeLV was added at the early stages of the culture, and could not be demonstrated when UV-FeLV was added 8 hr after initiation of the culture. These data therefore indicate that non-infectious feline leukemia viral particles can modify the production of feline IFNs by peripheral blood mononuclear cells.