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June 17, 2026Open Access

Efficacy and Safety of Polyherbal Formulations in the Management of Primary Dysmenorrhea: A Systematic Review

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Authors

MKMs. Jannat Diwate*1, Dr. Shailesh Patwekar2, Mr. Shubham Kamdi3, Ms. Pallavi Gondale4, Ms. Rutuja Patil5, Ms. Shreya Kadam6

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Implication

Systematic review shows polyherbal formulations reduce pain in women with primary dysmenorrhea, suggesting a viable alternative to NSAIDs.

Key Points

  • To evaluate the efficacy and safety of herbal and polyherbal interventions for primary dysmenorrhea.
  • Systematic review conducted per PRISMA 2020 guidelines
  • Search of databases for randomized controlled trials up to April 2026
  • Assessment of methodological quality using Cochrane RoB 2 tool.
  • Sixteen RCTs with 1,641 participants met inclusion criteria
  • Significant reductions in menstrual pain reported compared to placebo
  • Adverse events were mild, primarily gastrointestinal, and infrequent.

Cite This Study

Ms. Jannat Diwate*1, Dr. Shailesh Patwekar2, Mr. Shubham Kamdi3, Ms. Pallavi Gondale4, Ms. Rutuja Patil5, Ms. Shreya Kadam6 (2026) studied this question.

synapsesocial.com/papers/6a323f5ed50b63ecad208096https://doi.org/10.5281/zenodo.20696378
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EFFICACY AND SAFETY OF POLYHERBAL FORMULATIONS IN THE MANAGEMENT OF PRIMARY DYSMENORRHEA: A SYSTEMATIC REVIEW2026
  2. 2Efficacy of Plant‐Derived Therapies for Primary Dysmenorrhea: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials2026
  3. 3A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea2014 · 25 citations
  4. 4The Effect of Ginger, Cinnamon, and Fennel on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis2025
  5. 5The Effectiveness of Ginger in Managing Dysmenorrhea: A Scoping Review2026