Key result
TGF-beta upregulates ET-1 expression in endothelial cells through functional cooperation between Smad proteins and activator protein-1 via the coactivator CBP/p300.
Population
Endothelial cells
Design
Preclinical
Authors
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Hypothesis-generating for ET-1 modulation in vascular disease; leaves open clinical translation.
The study elucidates the molecular mechanism of TGF-beta-induced Endothelin-1 expression, highlighting the essential cooperation between Smad proteins and AP-1 in endothelial cells.
Rodríguez‐Pascual et al. (2003) studied this question. Transforming growth factor-beta (TGF-beta) was evaluated on Endothelin-1 (ET-1) expression and transcriptional activation. TGF-beta upregulates ET-1 expression in endothelial cells through functional cooperation between Smad proteins and activator protein-1 via the coactivator CBP/p300.
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