Key result
TGF-β1 induced release of endothelin-1 is PPAR-γ dependent in cultured A549 cells, mediated through the p38 MAPK and Smad2 signaling pathways.
p-value: p=<0.05
TGF-β1 induced release of endothelin-1 is PPAR-γ dependent in cultured A549 cells, providing mechanistic insights into pulmonary vascular remodeling.
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Leaves open PPAR-γ targeting in pulmonary vascular remodeling; requires in vivo validation before any clinical consideration.
Xiang et al. (2016) studied Pulmonary arterial hypertension (in vitro model). TGF-β1 and PPAR-γ modulators (S2505, S2871, SB203580) vs. Vehicle control (0.1% DMSO) or negative plasmid was evaluated on Endothelin-1 (ET-1) mRNA and protein expression (p=<0.05). TGF-β1 induced release of endothelin-1 is PPAR-γ dependent in cultured A549 cells, mediated through the p38 MAPK and Smad2 signaling pathways.
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