Key result
TGF-beta2 increased ET-1 mRNA and peptide levels in rat vascular endothelial and smooth muscle cell cultures, suggesting TGF-beta regulates vascular endothelin expression.
Population
Rat vascular endothelial cells (EC), vascular smooth muscle cells (VSMC), and vascular organ cultures
Comparison
Transforming growth factor-beta 2 and… vs Untreated control cultures (implied)
Design
Preclinical
Authors
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Hypothesis-generating for TGF-beta–ET-1 vascular regulation; leaves open clinical relevance and should not change practice.
TGF-beta promotes endothelin expression in vascular cells and organ cultures, suggesting a role in regulating cardiovascular function.
Gonzalez et al. (2001) studied this question. TGF-beta2 was evaluated on ET-1 mRNA and peptide levels. TGF-beta2 increased ET-1 mRNA and peptide levels in rat vascular endothelial and smooth muscle cell cultures, suggesting TGF-beta regulates vascular endothelin expression.
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