Key result
DCM is linked to ~51% lower myocardial PCr and depleted ATP vs. healthy controls.
Why the study?
What are the absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium as measured by 31P-SLOOP MRS?
Population
40 subjects divided into 4 groups: normal volunteers, patients with hypertensive heart disease, aortic…
Comparison
31P-SLOOP magnetic resonance spectroscopy and… vs Normal volunteers
Design
Cross-sectional
Authors
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Absolute quantification of myocardial metabolites using 31P-MRS reveals that both PCr and ATP are significantly reduced in dilated cardiomyopathy, demonstrating that relative ratios underestimate energetic depletion in heart failure.
Cross-Sectional (n=40)
What are the absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium as measured by 31P-SLOOP MRS?
Absolute quantification of myocardial metabolites using 31P-MRS reveals that both PCr and ATP are significantly reduced in dilated cardiomyopathy, demonstrating that relative ratios underestimate energetic depletion in heart failure.
Beer et al. (2002) conducted a cross-sectional in Hypertensive heart disease, aortic stenosis, and dilated cardiomyopathy (n=40). Cardiac hypertrophy and failure (HHD, aortic stenosis, DCM) vs. Healthy volunteers was evaluated on Absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP). In patients with dilated cardiomyopathy, absolute concentrations of myocardial phosphocreatine and ATP were reduced by 51% and 35% respectively compared to healthy volunteers.
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