Key result
Apolipoprotein A-I and high-density lipoprotein demonstrate anti-tumorigenic properties in clinical and animal studies, likely by modulating the tumor microenvironment and immune response.
Design
Review
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Hypothesis-generating for apoA-I/HDL modulation in oncology; leaves open whether raising levels alters cancer incidence or outcomes in humans.
This review highlights the emerging role of apoA-I and HDL in tumor biology, suggesting their atheroprotective mechanisms may also confer anti-tumorigenic benefits.
Zamanian-Daryoush et al. (2015) conducted a review in Cancer. Apolipoprotein A-I and High-density lipoprotein (HDL) was evaluated. Apolipoprotein A-I and high-density lipoprotein demonstrate anti-tumorigenic properties in clinical and animal studies, likely by modulating the tumor microenvironment and immune response.
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