Key result
Oral diazepam premedication prior to cardiac catheterization or PCI did not significantly alter the composite of access site complications and vasovagal events (25% vs 22%, P=.145).
Why the study?
Does premedication with oral diazepam reduce access site complications, anxiety, and pain in patients undergoing cardiac catheterization or percutaneous coronary intervention?
Population
760 consecutive patients scheduled to undergo either cardiac catheterization or percutaneous coronary…
Comparison
Oral diazepam 5-10 mg 30 to 60 minutes prior to… vs No premedication
Design
RCT, randomized
Follow-up
periprocedural
Authors
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Oral diazepam appears safe for access complications; extends RCT evidence supporting its use to reduce periprocedural pain.
RCT (n=760)
randomized
Does premedication with oral diazepam reduce access site complications, anxiety, and pain in patients undergoing cardiac catheterization or percutaneous coronary intervention?
Absolute Event Rate: 25% vs 22%
p-value: p=.145
Premedication with oral diazepam before cardiac catheterization or PCI reduces periprocedural pain without increasing access site complications.
Woodhead et al. (2007) conducted an RCT in Cardiac catheterization or percutaneous coronary intervention (n=760). Oral diazepam vs. No premedication was evaluated on Composite of hematoma (>=3 cm), pseudoaneurysm (requiring surgical repair), arterial bleeding (requiring further compression), and vasovagal events (p=.145). Oral diazepam premedication prior to cardiac catheterization or PCI did not significantly alter the composite of access site complications and vasovagal events (25% vs 22%, P=.145).
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