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This work investigates the significance of HLA-DQ antibody evaluation in kidney transplantation and its implications for understanding alloimmunity.

The Alpha-beta Soup of HLA-DQ: A Recipe for Alloimmune Perspectives

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Randomized trial evaluates the role of HLA-DQ antibody analysis in kidney transplant outcomes, highlighting knowledge gaps.

This work investigates the significance of HLA-DQ antibody evaluation in kidney transplantation and its implications for understanding alloimmunity.
Retrospective analysis of kidney transplant recipients from three centers in Paris
Evaluation of HLA-DQα DSA with previously gathered data from DQβ-only analysis
Assessment of associations between preformed HLA-DQ antibodies and antibody-mediated rejection outcomes
39.6% of patients originally categorized with DSA had non-relevant HLA-DQ targets after DQα analysis
Higher risk for antibody-mediated rejection associated with preformed antibodies observed at the three-month protocol biopsy
Significant correlation between preformed HLA-DQαβ DSA and increased microvascular inflammation scores

Anat R. Tambur (2026) studied this question.

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