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June 19, 2026ClinicsOpen Access

The impact of neonatal respiratory distress syndrome on subsequent preschool wheezing in very preterm infants: a multicenter cohort study

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Authors

XZXiaoting ZhangYLYan LiXZXiaoyun Zhong

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Overview

Multicenter cohort study investigates current wheezing in preterm infants linked to neonatal RDS, suggesting need for monitoring.

Key Points

  • This study examines the link between neonatal respiratory distress syndrome and later wheezing in preschool-aged very preterm infants.
  • Enrolled 525 infants born at < 32-weeks’ gestation from three hospitals in Southwest China.
  • Classified infants into RDS (n=275) and non-RDS (n=250) groups.
  • Assessed wheezing outcomes using the ISAAC questionnaire at 3–6 years.
  • RDS group had a higher incidence of wheezing at 11.3% compared to 5.6% in the non-RDS group (aOR = 2.45, 95% CI 1.20–4.98).
  • Elevated risks were observed in females and infants born at 28⁺⁰–29⁺⁶ weeks and those with low birth weights.
  • Findings were supported by sensitivity analyses, reinforcing the association between RDS and wheezing.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a34dc9f65a5b0777af2cb11https://doi.org/10.1016/j.clinsp.2026.101023
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