What does this research mean for the field?

Increased neonatal respiratory resistance (Rrs) is associated with more wheezing illnesses during infancy, while reduced neonatal compliance (Crs) is associated with more wheezing illnesses during the first 5 years of life, late-onset or persistent wheezing, and asthma at age 5. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the link between neonatal lung function metrics and wheezing consultations in early childhood.

March 14, 2026European Respiratory Journal

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

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Authors

AGAnne van der Gugten CUCSPM Uiterwaal TVTheo Verheij

Discussion

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Overview

Cohort study examines lung function and wheezing consultations in infants, suggesting implications for asthma risk.

Key Points

To evaluate the link between neonatal lung function metrics and wheezing consultations in early childhood.
Infants were part of the WHISTLER birth cohort on wheezing illnesses.
Single occlusion technique (SOT) used during natural sleep before 2 months of age.
Wheezy consultations were tracked using electronic patient files.
Poisson regression analyzed associations between lung function measures and consultations.
Non-parametric tests compared lung function values across wheezing phenotypes.
Each increase in resistance (Rrs) was linked to a 9% rise in consultations within the first 3 years.
An increase in compliance (Crs) indicated a 17% reduction in consultations during the first 3 years and 29% in the 4th-5th year.
Children with late-onset/persistent wheezing and asthma showed lower Crs values than peers.

Cite This Study

Gugten et al. (2011) studied this question.

synapsesocial.com/papers/69b4fb9db39f7826a300be07 https://doi.org/10.1183/13993003/erj.38.suppl_55.3403

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March 14, 2026European Respiratory Journal

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

View Full Paper

Ask AI

Bookmark

Authors

AGAnne van der Gugten CUCSPM Uiterwaal TVTheo Verheij

Discussion

Member takes

Overview

Cohort study examines lung function and wheezing consultations in infants, suggesting implications for asthma risk.

Key Points

To evaluate the link between neonatal lung function metrics and wheezing consultations in early childhood.
Infants were part of the WHISTLER birth cohort on wheezing illnesses.
Single occlusion technique (SOT) used during natural sleep before 2 months of age.
Wheezy consultations were tracked using electronic patient files.
Poisson regression analyzed associations between lung function measures and consultations.
Non-parametric tests compared lung function values across wheezing phenotypes.
Each increase in resistance (Rrs) was linked to a 9% rise in consultations within the first 3 years.
An increase in compliance (Crs) indicated a 17% reduction in consultations during the first 3 years and 29% in the 4th-5th year.
Children with late-onset/persistent wheezing and asthma showed lower Crs values than peers.

Cite This Study

Gugten et al. (2011) studied this question.

synapsesocial.com/papers/69b4fb9db39f7826a300be07 https://doi.org/10.1183/13993003/erj.38.suppl_55.3403

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