Shows regioselective chemical reactions in alkynes, indicating novel synthetic pathways.
The gold-catalyzed addition of phenols, alcohols, and carboxylic acids to 2,2,2-trifluoroethyl-substituted alkynes is reported. The reaction is highly regioselective, once again illustrating the strong directing effect of the trifluoromethyl group in gold-catalyzed additions to alkynes through its inductive influence.
No takes yet. Share an insight, caveat, or question.
Pronovost et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: