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Evaluate the efficacy and biocompatibility of bacterial cellulose dressings functionalized with grapefruit seed oil for diabetic wound healing.

June 19, 2026PolysaccharidesOpen Access

Bacterial Cellulose Dressings from Mango Pulp Agro-Waste Functionalized with Grapefruit Seed Oil for Diabetic Wound Healing

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Preclinical evaluation of BC dressings for diabetic wound healing, suggesting a sustainable solution from agro-waste.

Evaluate the efficacy and biocompatibility of bacterial cellulose dressings functionalized with grapefruit seed oil for diabetic wound healing.
BC membranes were obtained from mango pulp using Komagataeibacter xylinus cultivation at 6.32 g/L.
GSO was added at three v/v ratios (1:100, 1:200, 1:500) and assessed for antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans.
In vivo testing was conducted in a diabetic Wistar rat model for wound healing evaluation.
The BC/GSO 1:500 formulation showed >70% cell viability and no mutagenicity, pyrogenicity, or sensitization.
In vivo testing indicated that BC/GSO dressings supported wound closure similar to nitrofurazone, without signs of infection.

García-Sánchez et al. (2026) studied this question.

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