Dietary Purple Sweet Potato Anthocyanin Extracts Attenuate Intestinal Barrier Decline in Naturally Aged Mice Via the Microbiota-Autophagy-Stem Cell Axis

Yanpei Gu; Lulu Li; H Steve Zhang; Tong Ye; Qing Zhu; Xinru Zhao; Keqin Xie; Rui Ge; Jianzhong Han; Yumei Qin

doi:10.1039/d6fo00039h

January 1, 2026Food & Function

Dietary Purple Sweet Potato Anthocyanin Extracts Attenuate Intestinal Barrier Decline in Naturally Aged Mice Via the Microbiota-Autophagy-Stem Cell Axis

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Key Points

To investigate the impact of dietary purple sweet potato anthocyanin extracts on the intestinal barrier in naturally aged mice.
Used naturally aged mice to assess the effects of anthocyanin extracts on intestinal health.
Evaluated the microbiota, autophagy, and stem cell activity involved in intestinal barrier function.
Anthocyanin extracts significantly improved intestinal barrier integrity in aged mice, as shown by increased tight junction protein expression.
Improved microbiota composition associated with enhanced autophagy and stem cell activation was observed, indicating a functional response.
Showing a notable reduction in inflammatory markers linked to aging.

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Implication

Shows anthocyanin extracts enhance intestinal barrier function in aged mice, suggesting dietary strategies for aging health.

Abstract

Age-related deterioration of the intestinal epithelial barrier exacerbates systemic metabolic and functional decline, highlighting the gut as a key target for dietary interventions in healthy aging. Here, using naturally aged...

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Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/6a34de4165a5b0777af2daea https://doi.org/10.1039/d6fo00039h

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Dietary Purple Sweet Potato Anthocyanin Extracts Attenuate Intestinal Barrier Decline in Naturally Aged Mice Via the Microbiota-Autophagy-Stem Cell Axis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Dietary Purple Sweet Potato Anthocyanin Extracts Attenuate Intestinal Barrier Decline in Naturally Aged Mice Via the Microbiota-Autophagy-Stem Cell Axis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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