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June 19, 2026Food & Function

Dietary Purple Sweet Potato Anthocyanin Extracts Attenuate Intestinal Barrier Decline in Naturally Aged Mice Via the Microbiota-Autophagy-Stem Cell Axis

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Authors

YGYanpei GuLLLulu LiHZH Steve Zhang

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Overview

Randomized trial shows anthocyanin extracts enhance intestinal barrier function in aged mice, suggesting dietary strategies for aging health.

Key Points

  • To investigate the impact of dietary purple sweet potato anthocyanin extracts on the intestinal barrier in naturally aged mice.
  • Used naturally aged mice to assess the effects of anthocyanin extracts on intestinal health.
  • Evaluated the microbiota, autophagy, and stem cell activity involved in intestinal barrier function.
  • Anthocyanin extracts significantly improved intestinal barrier integrity in aged mice, as shown by increased tight junction protein expression.
  • Improved microbiota composition associated with enhanced autophagy and stem cell activation was observed, indicating a functional response.
  • Showing a notable reduction in inflammatory markers linked to aging.

Cite This Study

Gu et al. (2026) studied this question.

synapsesocial.com/papers/6a34de4165a5b0777af2daeahttps://doi.org/10.1039/d6fo00039h
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Super-Aged Microminipig Model for the Development of Health Foods for the Elderly: A Pilot Study on the Administration of Sweet Potato Petiole and Leaf Powder2025
  2. 2The Diet–Microbiota–Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications2026
  3. 3Abstract 2463: Microbiota-dependent complex dietary polysaccharide degradation suppresses inflammaging and colorectal cancer susceptibility2026
  4. 4Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling2026
  5. 5Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions2026 · 2 citations