Demonstrates how cellular mechanics influence immune suppression in regulatory T cells, suggesting a new understanding of immune responses.
Regulatory T cells (Tregs) suppress immune responses through multiple mechanisms, including contact-dependent removal of pMHCII and costimulatory ligands from antigen-presenting cells via trogocytosis and trans-endocytosis. These pathways require membrane deformation, receptor engagement, and vesicular trafficking. We propose that Treg efficiency in these processes is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.
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Arteaga-Muñiz et al. (2026) studied this question.
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