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Vanillin plus pentoxifylline outperforms monotherapy in reducing rat myocardial injury via Akt/HIF-1α/VEGF signaling.
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were increased. Treatment with either Van or PTX ameliorated ISO-induced changes and further upregulated Akt/HIF-1α/VEGF signaling. Furthermore, Van + PTX combination was more effective than monotherapy. These findings suggest a novel therapeutic potential of Van and PTX in ameliorating MI through enhancing cardiac angiogenesis and modulating oxidative stress, inflammation and apoptosis.
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Elseweidy et al. (2023) studied this question. A combination of vanillin and pentoxifylline was more effective than monotherapy in ameliorating isoproterenol-induced myocardial injury in rats via the Akt/HIF-1α/VEGF signaling pathway.
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