Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026Scientific ReportsOpen Access

Design of a triplex fluorescence aptasensor for a culture-free diagnosis of peritoneal dialysis-related peritonitis

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAwatef AltabbanARAmina RhouatiAAAreej I. Alhazmi

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates rapid diagnosis of peritonitis in dialysis, highlighting a novel culture-free approach.

Key Points

  • The aim is to develop a rapid, culture-free diagnostic tool for peritoneal dialysis-related peritonitis.
  • Developed a triplex fluorescence aptasensor for Staphylococcus aureus and Pseudomonas aeruginosa detection.
  • Utilized an unlabelled aptamer and fluorophore- and quencher-labeled complementary strands.
  • Tested sensor performance in sterilized clinical peritoneal fluid.
  • Aptasensors exhibited high sensitivity and specificity against non-target organisms.
  • Fluorescence restoration confirmed successful pathogen detection.
  • Demonstrated robust performance in clinical peritoneal fluid samples.

Cite This Study

Altabban et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535d9bhttps://doi.org/10.1038/s41598-025-27637-y
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, Development, and Method Evaluation of Aptamer-Based Diagnostics for the Detection of Multidrug-Resistant Bacteria2024
  2. 2A Novel Aptamer Selection Strategy for <em>Pseudomonas aeruginosa </em>and Its Application as a Detecting Probe in a Hybrid Lateral Flow Assay2025 · 1 citations
  3. 3A Novel Aptamer Selection Strategy for Pseudomonas aeruginosa and Its Application as a Detecting Probe in a Hybrid Lateral Flow Assay2025 · 4 citations
  4. 4Test Strips Based on Gated Nanoporous Anodic Alumina for the Rapid and Accurate Detection of <i>Pseudomonas aeruginosa</i> in Clinical Samples2026
  5. 5Label-Free Aptasensor Based on Functionalized Multiwalled Carbon Nanotubes for the Detection of Methicillin-Susceptible <i>Staphylococcus aureus</i>2026