Fundamental Concepts of Interactions between Drugs and Foods or Nutrients

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Key Points

This review aims to systematically organize the fundamental concepts and mechanisms of interactions between drugs and food components from pharmacokinetic and pharmacodynamic perspectives.
Comprehensive literature review of drug-food interactions related to absorption and metabolism.
Classification of interaction mechanisms involving drug metabolism enzymes and transporters.
Discussion of biopharmaceutical classification and its relevance to diet influences on drug efficacy.
Highlight the complexity and individual variability in food components affecting drug interactions.
Showed that a better understanding of drug and nutrient interactions can improve risk assessment in pharmacotherapy.
Emphasized the bidirectional relationship between drug metabolism and nutritional status, enhancing therapeutic outcomes.

Review discusses drug-food interactions, focusing on pharmacokinetics and pharmacodynamics, suggesting implications for clinical practice.

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Katsuyoshi Sunaga (2026) studied this question.

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