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June 20, 2026Psychological MedicineOpen Access

Transdiagnostic Biomarkers and Mechanistic Heterogeneity in Cognitive Fatigue: A Response to Rudroff

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Authors

SLStefanie LinnhoffRKRoi Cohen KadoshTZTino Zaehle

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Overview

Transdiagnostic approach identifies biomarkers in cognitive fatigue, suggesting diverse underlying mechanisms.

Key Points

  • This research aims to explore the transdiagnostic biomarkers associated with cognitive fatigue and the varying mechanistic pathways involved.
  • Analyzed existing literature on cognitive fatigue across different diagnoses.
  • Identified and characterized biomarkers linked to cognitive fatigue.
  • Examined physiological and psychological mechanisms influencing fatigue.
  • Found multiple biomarkers correlated with cognitive fatigue across various conditions.
  • Identified heterogeneous mechanistic pathways, indicating complexity in cognitive fatigue presentation.
  • Suggested that interventions may need to be tailored based on specific biomarkers identified.

Cite This Study

Linnhoff et al. (2026) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a536573https://doi.org/10.1017/s0033291726104929
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Also Consider

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  4. 4Biomarker-Informed Machine Learning Model of Cognitive Fatigue from a Heart Rate Response Perspective2021 · 21 citations
  5. 5Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles2026