Rhodium-Catalyzed Enantioselective Intermolecular C–H Silylation of Simple Arenes: Synergistic Substituent Effects Overcome Silane Redistribution to Enable Synthesis of Si-Stereogenic Arylsilanes

Lichuan Liu; Xingliang Chen; Guiyu Guan; Xinyue Su; Mengqing Liu; Yuefei Hu; Wei He; L J Zhang; Wenpeng Ma; Kun An

doi:10.1039/d6sc01404f

January 1, 2026Chemical ScienceOpen Access

Rhodium-Catalyzed Enantioselective Intermolecular C–H Silylation of Simple Arenes: Synergistic Substituent Effects Overcome Silane Redistribution to Enable Synthesis of Si-Stereogenic Arylsilanes

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Key Points

This research aims to explore the potentials of rhodium-catalyzed C–H silylation for synthesizing Si-stereogenic arylsilanes.
Utilized rhodium catalysts for C–H silylation of simple arenes.
Investigated the effects of different substituents on the reaction outcome.
Focused on overcoming silane redistribution in the process.
Achieved significant enantioselectivity in the synthesis of arylsilanes with specific substituents.
Established a clear correlation between substituent effects and reaction efficiency.
Showed the ability to synthesize a variety of Si-stereogenic arylsilanes successfully.

Implication

Demonstrates effective silylation of arenes, indicating a breakthrough in organosilicon synthesis.

Abstract

The non-directed intermolecular C–H bond silylation has manifested itself as a versatile tool for the access of organosilicon compounds, however the corresponding asymmetric transformations remain elusive primarily due to the...

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a362f63db0793dc1a536de4 https://doi.org/10.1039/d6sc01404f

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Rhodium-Catalyzed Enantioselective Intermolecular C–H Silylation of Simple Arenes: Synergistic Substituent Effects Overcome Silane Redistribution to Enable Synthesis of Si-Stereogenic Arylsilanes

Key Points

Implication

Abstract

Discussion

Cite This Study

Rhodium-Catalyzed Enantioselective Intermolecular C–H Silylation of Simple Arenes: Synergistic Substituent Effects Overcome Silane Redistribution to Enable Synthesis of Si-Stereogenic Arylsilanes

Key Points

Implication

Abstract

Discussion

Cite This Study

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