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June 20, 2026Schizophrenia Research CognitionOpen Access

Neuroanatomical and transcriptomic correlates of attention in schizophrenia

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Authors

HLHong-Liang LuXWX J WangDWDi Wu

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Overview

Cross-sectional study investigates attention, brain structure, and gene expression in schizophrenia, suggesting clinical significance for diagnosis and treatment strategies.

Key Points

  • This study aims to explore the relationship between attentional behavior, brain structure, and gene expression in schizophrenia.
  • Cross-sectional design with 137 participants: 65 schizophrenia patients and 72 healthy controls.
  • Participants underwent magnetic resonance imaging and cognitive tests to assess attention.
  • Correlation analyses were conducted between attentional performance and brain structure and gene expression.
  • Patients took significantly longer to respond in attention tasks than controls (all p < 0.05).
  • Structural brain changes included enlarged bilateral pallidum and reduced cortical thickness (all p < 0.05).
  • A significant correlation was found between attentional performance and pallidum volume (r = 0.42, p = 4.30 × 10 −4) specifically in patients.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a537006https://doi.org/10.1016/j.scog.2026.100452
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia2024 · 75 citations
  2. 2Schizophrenia Is a Cognitive Illness2013 · 845 citations
  3. 3Reduced striatal dopamine synthesis capacity in patients with schizophrenia during remission of positive symptoms2019 · 70 citations