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September 12, 2025

Cognitive modes underlying attentional control impairments in schizophrenia: an fMRI study

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Authors

AMAva MomeniPMPaul D. MetzakMEMaddie Evora

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Overview

Functional MRI reveals deficits in attentional control and cognitive modes in schizophrenia, suggesting targeted interventions.

Key Points

  • Participants with schizophrenia exhibited significant impairments in attentional control during cognitive tasks, emphasizing the cognitive control deficits associated with the disorder.
  • The study utilized fMRI to assess blood-oxygenation-level-dependent (BOLD) changes across different cognitive tasks, revealing distinct patterns in cognitive modes.
  • Three cognitive modes were identified: Multiple Demand, Language, and Default mode, with varying activity levels in individuals with schizophrenia compared to neurotypical participants.
  • Findings suggest that understanding specific cognitive modes may guide the development of neuromodulation techniques to restore cognitive function in schizophrenia.

Cite This Study

Momeni et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7331b076d99fa56b65https://doi.org/10.31234/osf.io/zyvq2_v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distinct Neural Activation Patterns in Executive Functions of Schizophrenia Patients with Predominant Positive and Negative Symptoms: An fNIRS Study2025
  2. 2Neuroanatomical and transcriptomic correlates of attention in schizophrenia2026
  3. 3Working Memory Dysfunction: An fMRI Analysis in Schizophrenia2025
  4. 4Neural correlates of set-shifting: decomposing executive functions in schizophrenia2010 · 1 citations
  5. 5Prefrontal Cortex Activation During Verbal Fluency Task and Tower of London Task in Schizophrenia and Major Depressive Disorder2021 · 21 citations