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June 20, 2026Advanced Pharmaceutical BulletinOpen Access

Combination therapy of cisplatin and naturally induced exosomes from treated HeLa cells: A novel drug-free strategy for cervical cancer treatment

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Authors

SASanaz AghajaniNVNasim VousooghiAHAbbas Hajifathali

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Overview

Randomized trial demonstrates apoptosis in HeLa cells using exosomes, suggesting a drug-free approach for cancer therapy.

Key Points

  • This study investigates whether exosomes from cisplatin-treated HeLa cells can induce apoptosis in untreated HeLa cells without carrying the drug.
  • Exosomes were extracted from cisplatin-treated HeLa cells via ultracentrifugation.
  • The MTT assay identified the optimal exosome dosage for triggering apoptosis.
  • Flow cytometry and qRT-PCR assessed apoptosis levels and gene expression.
  • 57.6% of recipient HeLa cells underwent apoptosis when exposed to exosomes from treated cells.
  • Increased expression of apoptotic markers BAX, Caspase-3, TP53, and TNF-α was observed with decreased BCL2 and BIRC5 levels.
  • The apoptotic effect was specific to cancerous cells with no impact on non-cancerous HEK293 cells.

Cite This Study

Aghajani et al. (2026) studied this question.

synapsesocial.com/papers/6a363123db0793dc1a53805bhttps://doi.org/10.34172/apb.46428
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