Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026Current Bioactive Compounds

Aegeline-rich Aegle marmelos Leaf Extract Mitigates Parkinson’s Disease Pathology associated with Mitochondrial ROS generation and α-SynucleinPhosphorylation

View Full Paper
Ask AI
Bookmark
Share

Authors

NKNishad KeethedethCSChinthu V. SajiSSSangeetha Sathyapalan

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates improved neuroprotection in a model of Parkinson’s disease, suggesting potential therapeutic benefits.

Key Points

  • This study aims to evaluate the efficacy of aegeline-rich Aegle marmelos extract in mitigating Parkinson's disease pathology.
  • Sequential extraction of A. marmelos leaves to obtain aegeline-rich extract (AMCE).
  • Characterization of AMCE using RP-HPLC and assessment of its antioxidant and iron-chelation activities.
  • Evaluation of cytotoxicity, mitochondrial ROS levels, and effects on alpha-synuclein phosphorylation in SH-SY5Y neuronal cells.
  • AMCE exhibited significantly higher antioxidant and iron-chelating activity compared to pure aegeline.
  • Both AMCE and aegeline showed neuroprotective effects up to 82% and were non-toxic at concentrations up to 5 μg/mL.
  • AMCE completely inhibited mitochondrial ROS production at 10 μg/mL, and both compounds reduced alpha-synuclein phosphorylation.

Cite This Study

Keethedeth et al. (2026) studied this question.

synapsesocial.com/papers/6a363147db0793dc1a538408https://doi.org/10.2174/0115734072471976260510191120
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic Evaluation of Aegle marmelos-Derived Compounds: Potential Therapeutic Agents Against Inflammation and Oxidative Stress2024 · 3 citations
  2. 2Aegeline mitigates isoproterenol-induced myocardial infarction: insights from biochemical, histopathological, and in silico studies2026
  3. 3IN SILICO AND PHARMACOLOGICAL EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT POTENTIAL OF SECONDARY METABOLITES FROM AEGLE MARMELOS2026
  4. 4Aegle marmelos (L.) Leaf Extract Improves Symptoms of Memory Loss Induced by Scopolamine in Rats2024 · 5 citations
  5. 5Assessment of the Anticancer Activity of Aegle marmelos Leaf Extracts Against Ehrlich's Ascites Carcinoma (EAC) Cell Line in Swiss Albino Mice2025