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This review examines the effects, characteristics, and implementation issues of AI-based interventions for depression and anxiety.

June 20, 2026F1000ResearchOpen Access

The Effects of Artificial Intelligence-Based Interventions on Depression and Anxiety: A Systematic Review

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Systematic review evaluates AI interventions for depression and anxiety, suggesting potential benefits and challenges.

This review examines the effects, characteristics, and implementation issues of AI-based interventions for depression and anxiety.
Performed a systematic review of 14 randomised controlled trials (RCTs) from databases like Scopus and PubMed.
Evaluated study quality using the Cochrane Risk of Bias 2 tool.
Synthesized findings through a narrative approach.
AI-based interventions showed effectiveness in reducing symptoms of depression and anxiety.
Outcomes varied, with some studies only reporting specific improvements within groups.
Implementation issues such as limited human support and recruitment bias affected adherence and generalizability.

Puspitarani et al. (2026) studied this question.

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