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Examines immunologic effects of viral infection on cancer incidence in mice, suggesting potential protective mechanisms.
Summary The effects of neonatal infection with radiation leukemia virus (RadLV) on subcutaneous sarcoma induced by 3-methylcholanthrene (MCA) were studied in C57BL/6 mice. Results indicated that neonatal RadLV infection reduced the incidence of MCA-induced sarcomas, an effect similar to that previously demonstrated with formalin-inactivated RadLV vaccine. The incidence of RadLV-induced leukemias was low and unaffected by MCA treatment. The possible immunologic factors involved in the prevention of MCA sarcoma were discussed.
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Carrie E. Whitmire (1973) studied this question.
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