What question did this study set out to answer?

The study aims to explore host immune responses in Toxoplasma gondii-infected rats by analyzing cytokine production and immune cell phenotypes.

June 21, 2026Al-Qadisiyah Journal of Veterinary Medicine SciencesOpen Access

Immunological assay and histopathological study of Toxoplasma gondii in Experimental male rats

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IAIhsan K. A. AlkardhiUniversity of Al-Qadisiyah NENésrine ElloumiHopital Universitaire Habib Bourguiba HMHatem MasmoudiCentre National de la Recherche Scientifique

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Implication

Randomized trial investigates immune responses to Toxoplasma gondii in experimental male rats, indicating effects on cytokine levels and immune cell profiles.

Key Points

The study aims to explore host immune responses in Toxoplasma gondii-infected rats by analyzing cytokine production and immune cell phenotypes.
40 male rats were infected with Toxoplasma gondii, compared to a control group of 10 rats.
Leukocytes in peripheral blood were stained and analyzed via flow cytometry.
Cytokine levels were assessed using quantitative ELISA at 12 and 30 days post-infection.
Infected rats showed significantly higher levels of IL-12, IFN-γ, IL-10, and IL-6 compared to controls.
Increased levels of CD14+ and CD19+ leukocytes were observed post-infection.
Histopathological analysis confirmed the presence of the bradyzoite stage in various organs including the liver, testis, brain, and kidney.

Cite This Study

Alkardhi et al. (2023) studied this question.

synapsesocial.com/papers/6a377f3a24f042ddf4c59de7 https://doi.org/10.29079/qjvms.2023.183393

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Implication

Randomized trial investigates immune responses to Toxoplasma gondii in experimental male rats, indicating effects on cytokine levels and immune cell profiles.

Immunological assay and histopathological study of Toxoplasma gondii in Experimental male rats

Discussion

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Implication

Key Points

Cite This Study

Immunological assay and histopathological study of Toxoplasma gondii in Experimental male rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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