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This study aims to assess the relationship between pre-existing type 2 diabetes mellitus and mortality risk in adults suffering from sepsis.

June 21, 2026CureusOpen Access

Association Between Type 2 Diabetes Mellitus and Sepsis Outcomes: A Systematic Review and Meta-Analysis

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This study aims to assess the relationship between pre-existing type 2 diabetes mellitus and mortality risk in adults suffering from sepsis.
Conducted a systematic review and meta-analysis following PRISMA guidelines.
Systematic searches were performed across PubMed, Cochrane CENTRAL, and Google Scholar databases.
Pooled odds ratios were calculated using a random-effects model from qualifying observational studies.
The pooled analysis showed no significant association between T2DM and sepsis mortality (OR = 0.99; 95% CI = 0.82-1.20).
Substantial heterogeneity was observed across studies (I² = 98.4%).
Glycemic status, diabetes-related complications, and organ dysfunction were suggested to be more critical in determining outcomes.

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Systematic review evaluates the association of pre-existing T2DM and sepsis mortality, suggesting glycemic factors may be more impactful.

Gade et al. (2026) studied this question.

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