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This review aims to explore how Type 2 diabetes mellitus affects sepsis onset and progression.

The interplay between type 2 diabetes mellitus and sepsis: a scoping review

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This review aims to explore how Type 2 diabetes mellitus affects sepsis onset and progression.
Mapped 33 studies sourced from PubMed and Scopus until June 2025.
Examined immune, genetic, metabolic, prognostic, clinical, and treatment outcomes associated with T2DM and sepsis.
Provided insights into the effects of various interventions on sepsis outcomes in patients with T2DM.
Patients with T2DM exhibited higher susceptibility to infections and more severe multi-organ dysfunction.
C-peptide modulation by insulin influenced sepsis outcomes significantly.
Poor glycaemic control worsened sepsis outcomes and prolonged hospitalization.

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Scoping review maps outcomes of Type 2 Diabetes Mellitus and sepsis interactions, suggesting crucial insights for management.

Sham et al. (2026) studied this question.

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