Invasive Squamous Cell Carcinoma Arising in Long-Standing Chromoblastomycosis Requiring Limb Amputation: A Case Report

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Key Points

This report presents a case of invasive squamous cell carcinoma (SCC) developing from a long-standing chromoblastomycosis infection.
Presented a 77-year-old male with a chronic verrucous lesion on the right foot that progressed to an ulcer.
Histopathological examination identified well-differentiated invasive SCC with accompanying fibrosis and granulomatous inflammation.
Amputation was performed due to significant tissue destruction and loss of function.
Histopathological analysis showed good differentiation of SCC infiltrating the reticular dermis and numerous muriform bodies indicative of chromoblastomycosis.
The findings underline the carcinogenic potential of chronic inflammatory dermatoses.
The case emphasizes the need for careful histopathological evaluation and long-term follow-up in chronic chromoblastomycosis.

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Case report reveals invasive squamous cell carcinoma in a patient with chronic chromoblastomycosis, suggesting careful monitoring is necessary.

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Pedrosa et al. (2026) studied this question.

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