Key result
Computational modeling of atrial fibrillation provides novel insights into disease mechanisms and aids in identifying new drug targets, though pipelines for drug screening remain in their infancy.
Design
Review
Authors
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AF therapy requires multiscale integration of atrial mechanisms; leaves open identification of efficacious, ventricle-independent pharmacotherapies.
Computational modeling provides a scalable approach to integrate multiscale characteristics of atrial fibrillation pathophysiology for the rational design of atrial-specific pharmacotherapies.
Vagos et al. (2018) conducted a review in Atrial Fibrillation. Computational modeling was evaluated. Computational modeling of atrial fibrillation provides novel insights into disease mechanisms and aids in identifying new drug targets, though pipelines for drug screening remain in their infancy.
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