What is the clinical evidence from this study?

Study design: Other. Population: Experimental atrial fibrillation. Intervention: JTV-519. Primary outcome: Repolarizing K(+) currents and experimental atrial fibrillation threshold.

December 1, 2000British Journal of PharmacologyOpen Access

Inhibitory effects of JTV‐519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea‐pig hearts

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Key result

JTV-519 inhibited repolarizing K+ currents and prevented the induction of experimental atrial fibrillation in isolated guinea-pig hearts.

Why the study?

Does JTV-519 inhibit repolarizing K+ currents and prevent experimental atrial fibrillation in guinea-pig hearts?

Population

Guinea-pig atrial cells and isolated guinea-pig hearts

Comparison

JTV-519 (0.3 to 1 microM) vs Baseline or carbachol/adenosine/GTP gamma S alone

Design

Preclinical

Authors

HNHaruaki NakayaKeio University YFYoshie FurusawaKanazawa University TOTakehiko OguraKanagawa Cardiovascular and Respiratory Center

Discussion

Member takes

Implication

JTV-519 shows antiarrhythmic effects in guinea-pig hearts; leaves open translation to human AF.

Structured PICO

Does JTV-519 inhibit repolarizing K+ currents and prevent experimental atrial fibrillation in guinea-pig hearts?

Population

Guinea-pig atrial cells and isolated guinea-pig hearts

Intervention

JTV-519 (0.3 to 1 microM)

Comparator

Baseline or carbachol/adenosine/GTP gamma S alone

Outcome

Repolarizing K(+) currents (I(K.ACh), I(K)) and experimental atrial fibrillation parameters (monophasic action potential, effective refractory period, atrial fibrillation threshold)surrogate

JTV-519 demonstrates antiarrhythmic properties against atrial fibrillation in guinea-pig models by inhibiting repolarizing potassium currents.

Cite This Study

Nakaya et al. (2000) studied Experimental atrial fibrillation. JTV-519 was evaluated on Repolarizing K(+) currents and experimental atrial fibrillation threshold. JTV-519 inhibited repolarizing K+ currents and prevented the induction of experimental atrial fibrillation in isolated guinea-pig hearts.

synapsesocial.com/papers/6a39cd7fc5135fa86afa1e4b https://doi.org/10.1038/sj.bjp.0703713

Topics

Atrial fibrillation Persistent AF management

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Inhibitory effects of JTV‐519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea‐pig hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inhibitory effects of JTV‐519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea‐pig hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider