January 1, 1999The Japanese Journal of PharmacologyOpen Access

Effects of a Novel Cardioprotective Drug, JTV-519, on Membrane Currents of Guinea Pig Ventricular Myocytes

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Population

Guinea pig ventricular myocytes

Design

Preclinical

Authors

MKMasanori KawaharaMiyagi University SESakai EiichiMitsubishi Electric (Japan)YJYatabe JunichiFukushima Medical University

Discussion

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Implication

JTV-519's multi-channel blockade in myocytes may inform antiarrhythmic development; leaves open clinical utility pending human studies.

Structured PICO

Population

Guinea pig ventricular myocytes

Intervention

JTV-519 (various concentrations, e.g., 1 microM)

Outcome

Membrane currents (fast Na+ current, Ca2+ current, inwardly rectifying K+ current) and action potential duration/heightsurrogate

JTV-519 acts as a multi-channel blocker in guinea pig ventricular myocytes, exhibiting frequency- and voltage-dependent inhibition of sodium, calcium, and potassium currents.

Cite This Study

Kawahara et al. (1999) studied this question.

synapsesocial.com/papers/6a86a9db5ee22a1e35cb8a38 https://doi.org/10.1254/jjp.79.275

View Full Paper

Ask AI

Bookmark

Effects of a Novel Cardioprotective Drug, JTV-519, on Membrane Currents of Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of a Novel Cardioprotective Drug, JTV-519, on Membrane Currents of Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider