Why the study?
Does guanidine hydrochloride induce drug-resistant mutants in poliovirus in cell culture?
Population
Poliovirus in cell culture
Design
Preclinical
Authors
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Rapid in vitro resistance emergence cautions against guanidine monotherapy; leaves open in vivo relevance for poliovirus or other antivirals.
Does guanidine hydrochloride induce drug-resistant mutants in poliovirus in cell culture?
Poliovirus rapidly develops significant resistance to guanidine hydrochloride in cell culture, highlighting challenges in viral chemotherapy.
Melnick et al. (1961) studied this question.
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