Why the study?
Do soluble guanidine salts inhibit poliovirus and enteroviruses in cell cultures and animal models?
Population
Cell cultures and monkeys infected with poliovirus and other enteroviruses
Design
Preclinical
Authors
Loading...
Toxicity precludes clinical use; leaves open cell culture screening as a validated tool for enterovirus antiviral discovery.
Do soluble guanidine salts inhibit poliovirus and enteroviruses in cell cultures and animal models?
Guanidine salts exhibit antiviral activity against poliovirus in vitro and in vivo, validating cell culture screening methods despite the drug's severe toxicity preventing human use.
Rightsel et al. (1961) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: