Key result
RV apical pacing linked to ~19% lower systolic energy loss in HCM.
Why the study?
Right ventricular pacing can cause left ventricular dyssynchrony but is also a treatment option for hypertrophic obstructive cardiomyopathy, and its impact on left ventricular flow energy loss in patients with versus without hypertrophic cardiomyopathy is unclear.
Does right ventricular pacing alter left ventricular flow energy loss in patients with and without hypertrophic cardiomyopathy?
Cross-Sectional (n=36)
No
Does right ventricular pacing alter left ventricular flow energy loss in patients with and without hypertrophic cardiomyopathy?
Right ventricular pacing acutely decreases left ventricular systolic energy loss in patients with hypertrophic cardiomyopathy, contrasting with an increase observed in patients with normal left ventricular function.
Answers are grounded in this paper and cite their sources.
RV apical pacing may reduce systolic energy loss in HCM; hypothesis-generating and requires prospective trials before any clinical consideration.
Background Right ventricular (RV) pacing causes left ventricular (LV) dyssynchrony sometimes resulting in pacing‐induced cardiomyopathy. However, RV pacing for hypertrophic obstructive cardiomyopathy is one of the treatment options. LV flow energy loss (EL) using vector flow mapping (VFM) is a novel hemodynamic index for assessing cardiac function. Our study aimed to elucidate the impact of RV pacing on EL in normal LV function and hypertrophic cardiomyopathy (HCM) patients. Methods A total of 36 patients with dual‐chamber pacemakers for sick sinus syndrome or implantable cardioverter defibrillators for fatal ventricular tachyarrhythmias were enrolled. All patients were divided into two groups: 16 patients with HCM (HCM group) and others (non‐HCM group). The absolute changes in EL under AAI (without RV pacing) and DDD (with RV pacing) modes were assessed using VFM on color Doppler echocardiography. Results In the non‐HCM group, the mean systolic EL significantly increased from the AAI to DDD modes (14.0 ± 7.7 to 17.0 ± 8.6 mW/m, P = .003), whereas the mean diastolic EL did not change (19.0 ± 12.3 to 17.0 ± 14.8 mW/m, P = .231). In the HCM group, the mean systolic EL significantly decreased from the AAI to DDD modes (26.7 ± 14.2 to 21.6 ± 11.9 mW/m, P < .001), whereas the mean diastolic EL did not change (28.7 ± 16.4 to 23.9 ± 19.7 mW/m, P = .130). Conclusions RV pacing increased the mean systolic EL in patients without HCM. Conversely, RV pacing decreased the mean systolic EL in patients with HCM.
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Arakawa et al. (2020) conducted a cross-sectional in Hypertrophic cardiomyopathy (n=36). Right ventricular apical pacing (DDD mode) vs. Without right ventricular pacing (AAI mode) was evaluated on Mean systolic energy loss (ELsys) in patients with hypertrophic cardiomyopathy (p=<0.001). Right ventricular apical pacing decreased the mean systolic energy loss in patients with hypertrophic cardiomyopathy (from 26.7 to 21.6 mW/m, P<0.001), whereas it increased energy loss in patients without hypertrophic cardiomyopathy.
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